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Saturday, April 25, 2020 | History

2 edition of study of starch as a disintegrating agent in compressed formulations found in the catalog.

study of starch as a disintegrating agent in compressed formulations

Arnold G. Bergin

study of starch as a disintegrating agent in compressed formulations

  • 356 Want to read
  • 38 Currently reading

Published in Toronto .
Written in English

    Subjects:
  • Tablets (Medicine),
  • Starch

  • Edition Notes

    ContributionsToronto, Ont. University. Theses (B.Sc.Phm.)
    The Physical Object
    Pagination[33 leaves]
    Number of Pages33
    ID Numbers
    Open LibraryOL18448987M

    Yash Paul et al., formulated oral disintegrating tablets (ODT) of Zidovudine by using direct compression method. From the present study it can be concluded that oral dispersible tablets of zidovudine can be successfully prepared employing three different disintegrants viz. sodium starch glycollate, crosscarmellose sodium or crospovidone.   What is claimed is: 1. An aerosol starch formulation for use in finishing laundered textile garments comprising from about 2 to about 10 parts by weight of a liquefied normally gaseous propellant and from about 98 to about 90 parts by weight of an aqueous starch composition consisting essentially of water and from about 2 to about 6 percent by weight . The second volume in the six-volume Handbook of Pharmaceutical Manufacturing Formulations, this book covers uncompressed solids, which include formulations of powders, capsules, powders ready for reconstitution and other similar products from publicly available but widely dispersed information from FDA New Drug Applications (NDA), patent applications, and other sources of/5(9).


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study of starch as a disintegrating agent in compressed formulations by Arnold G. Bergin Download PDF EPUB FB2

GG has been used in tablet formulations as swelling agent, disintegrant, and binding agent. Several investigations have shown that GG is a good swelling agent, particularly when combined with other polysaccharides, but swelling degree depends on the type of gelling cations [47,48].

Pregelatinized starch (PGS) is a modified starch with multifunctional benefits. It can be used as a binder, disintegrant, and diluent in tablet formulations.

PGS is manufactured by rupturing all or part of the native starch granules using chemical and mechanical processing. Formulation Study for Orally Disintegrating Tablet Using Partly Pregelatinized Starch Binder Article in Chemical & pharmaceutical bulletin 59(8) August with Reads.

A study of natural sponge as a disintegrating agent in compressed tablets Article in Journal of the American Pharmaceutical Association 47(5) May with. a study of sponge as a disintegrating agent in compressed tablets by robert carl crisafi a dissertation presented to the graduate counol of the unnersity of florida in partial fulfilment of the requirements for the degree of doctor of philosophy university of page 2 1.

Hence, the study revealed that this natural disintegrant (fenugreek mucilage) showed more preponderant disintegrating property than the most widely used synthetic superdisintegrants like Ac-di-sol in the formulations of FDTs.

Studies betokened that the extracted mucilage is a good pharmaceutical adjuvant and concretely a disintegrating by: 8. Formulation study for orally disintegrating tablet using partly pregelatinized starch binder. Mimura K(1), Kanada K, Uchida S, Yamada M, Namiki N.

Author information: (1)Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, by: 8. disintegrating dosage forms are as follows: 1. Orally disintegrating tablets: It is a tablet that dissolves or disintegrates in the oral cavity without the need of water or chewing (Gupta et al, ).

Fast dissolving films: The fear of taking solid tablets and the risk of choking for certain patient population still existsFile Size: KB. ABSTRACT. The present study was undertaken to formulate directly compressible tablets to investigate the effect of different disintegrating agents such as maize starch and avicel PH on disintegration time, in vitro drug dissolution and their release properties.

Tablets of paracetamol and the combination of paracetamol and diclofenac using maize starch and avicel PH. Starch as Pharmaceutical Excipient A Review Article. Int. Pharm. Sci. Rev. Res., 41(2), November - December ; Article No.

14, Pages: ISSN – X the characteristics of the compressed tablets 8, In tablet formulations, freshly prepared corn starch paste is used at a concentration of 5–25% w/w in tablet File Size: 1MB.

The aim of this study is to find the effect of starch and guar gum on disintegrating time and dissolution behavior of drug Zolmitriptan from fast dissolving tablet (FDT).

The FDT was prepared by direct compression method. The precompression parameters were evaluated with subjected to angle of repose, bulk and tapped.

The objective of the present study was to prepare the fast disintegrating tablet of salbutamol sulphate for respiratory disorders for pediatrics.

As precision of dosing and patient's compliance become important prerequisites for a long-term treatment, there is a need to develop a formulation for this drug which overcomes problems such as Cited by: Starch etc.

Role of Super disintegrants in the manufacturing of tablets Disintegrating agents are substances included in tablet formulations and in some hard shell capsule formulations to promote moisture penetration and dispersion of the matrix of the dosage form in dissolution by: 1. The aim of this study was to evaluate the effect of increasing nifedipine load on the characteristics of fast-disintegrating sublingual tablets for the potential emergency treatment of anginal pain and hypertension.

Nifedipine undergoes first pass metabolism in liver and gut wall which has oral bioavailability of %. Formulation Study for Orally Disintegrating Tablet Using Partly Pregelatinized Starch Binder.

corn starch and partly pregelatinized starch, in order to design granules suited for orally disintegrating tablets composed of D-mannitol, corn starch or partly pregelatinized starch.

The effects of these 2 factors on 3 types of responses, namely Cited by: 8. Types and List of Tablet Disintegrants Starch (Amylum) The mechanism of action of starch is wicking and restoration of deformed starch particles on contact with aqueous fluid and in doing so release of certain amount of stress which is responsible for disruption of hydrogen bonding formed during compression.

The effect seemed to be larger at corn starch than potato starch. There should be the critical amount of starch necessary for the disintegration depending upon the particle size or the specific surface area of ingredients.

The smaller the particle size of aspirin, the more amount of starch was required for the tablet by: compression method using Crospovidone and Sodium starch glycolate as the super disintegrants.

Amongst all formulations, formulation F3 prepared by a combination of both Crospovidone and Sodium starch glycolate showed least disintegrating time, and faster dissolution of 87%.

The study of disintegrating property of all the formulations showed that the disintegration time for the tablets prepared with Musa paradisiaca starch was less than that of Corn starch Table 5 kumar et al J. Chem. Pharm. Res.,2(4): Author: kumar, N. Anilkumar, Rekha Rajeevkumar. In a study, MCC was used as disintegrating agent in the formulation of fast releasing compressed propranol hydrochloride suppositories as reported.

Watanabe (13, 14) used microcrystalline cellulose as disintegrant along with low substituted hydroxy propyl cellulose (L-HPC) to prepare rapidly disintegrating tablets. MODIFIED STARCHES IN PHARMACEUTICAL FORMULATIONS Starch is a naturally occurring polysaccharide that has been widely studied for many years in the field of materials1, 2.

It is used extensively in the production of both food and industrial products. Starch is a naturally occurring biodegradable material,File Size: KB. Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets.

The objective of the present study was to prepare the fast disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become important Cited by: 2.

The result of this study give an indication as to binding activity of sweet potato starch produce in Côte d’Ivoire butby wet granulation. Key words: granules, Sweet potato starch, binder, disintegrant. Introduction. Since the introduction of tablets into the pharmaceutical industry, corn starch has been recognizd as the one of the most eFile Size: 82KB.

Development and Evaluation of Orally Disintegrating Tablet by Direct Compression powder as flavouring agent and aspartame as sweetening agent, using croscarmellose sodium, sodium starch glycolate, crospovidone as superdisintegrant while other formulation component kept constant.

Nine formulations F1-F9 were prepared by varying the File Size: KB. The total 6 formulations (F1–F6) were prepared using different concentration of Sodium Starch Glycolate to study its effect on disintegration time. The results for optimization of superdisintegrant concentration in FDTs by direct compression method are shown in Table 5.

The present study was undertaken to formulate directly compressible tablets to investigate the effect of different disintegrating agents such as maize starch and avicel PH on disintegration time, in vitro drug dissolution and their release properties. Tablets of paracetamol and the combination of paracetamol and diclofenac using maize starch.

Binders, diluents, lubricants, disintegrating agent’s plasticizers etc, e.g.: when 5% starch is used in formulation it acts as a binder for tablet formulations where as when it is used in dry form it can perform the function of a disintegrant. Excipients that are used in liquid dosage forms are:. XVI.

Dyes in Formulations 20 XVII. Equipment 20 A. Blenders 20 1. Pony Pan 21 2. Ribbon 21 3. Tumbler 21 4. High-Shear (High-Energy) 21 5. Plastic Bag 22 B. Dryers 22 C. Tablet Compression Equipment 22 D. Coating Equipment 22 XVIII. Excipients 23 A. Coating Agent 23 B. Glidant 23 C.

Tablet Binder 23 D. Diluent 23 E. Disintegrant 23 F. Lubricant File Size: KB. Formulation and Taste Masking of Ranitidine Orally Disintegrating Tablet Zahra Hesaria, Akram Shafieeb, Shirin Hooshfarc, Naser Mobarrad and Seyed Alireza Mortazavic* aDepartment of Pharmaceutics, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.

bDeptartment of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences. The formulations that were produced contained hydrolyzed and unhydrolyzed gelatin as a support agent for the matrix, mannitol as a bulking agent, and sodium starch glycolate or crosscarmellose as a disintegrant.

Disintegration and dissolution was further enhanced by adding an acid (e.g., citric acid) or an alkali (e.g., sodium. Binders (allow drug power to be compressed into a solid tablet) cellulose, methyl cellulose, polyvinyl pyrrolidine, PEG, gelatin, PVP, HPMC, PEG, sucrose, starch Disintegrating agent (breaks hard solid tab to free the power drug from tablet) starch derivatives, clay, cellulose, alginates, PVP(povidone), cross linked Na CMCVeegum HV, Betonite.

The first volume in the six-volume Handbook of Pharmaceutical Manufacturing Formulations, this book covers the largest category of pharmaceutical formulations, compressed solids, which include formulations of tablets and other compressed solids from publicly available but widely dispersed information from FDA New Drug Applications (NDA), patent applications, and other 5/5(1).

This is Pharmaceutical topic - Orally disintegrating tablets. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website. minutes. The blend was then compressed on rotary tablet press (B tooling, Cadmach, India) using 8-mm diameter circular standard concave punches.

Nine batches were prepared with a target mass of mg (Formulations codes F1–F9). The composition of these formulations is shown in Table 1. Evaluation of Tablets [4, 11, 12]File Size: KB. Pharmaceutical formulations remain as much an art today as they have evolved into complex science.

With exponential growth of generic formulations, the need for ready formulations has increased. Essentially a cookbook for making drugs, the six-volume handbook contains the recipes and process steps for over drugs, including a number of. Ravichandiran 1, K. Masilamani 2, B.

Senthilnathan 2, S. Hariprasad 1 and D. Joseprakash 2. 1 Vels college of Pharmacy, Pallavaram, Chennai India. 2 Department of Pharmaceutics, Vels college of Pharmacy India. Corresponding Author E-mail:[email protected] Abstract.

The aim of the present study was to prepare and characterize mouth dissolving tablet of. The second volume in the six-volume Handbook of Pharmaceutical Manufacturing Formulations, this book covers uncompressed solids, which include formulations of powders, capsules, powders ready for reconstitution and other similar products from publicly available but widely dispersed information from FDA New Drug Applications (NDA), patent applications, and other sources of Format: Kindle.

minutes in the mouth before swallowing. Fast disintegrating tablets The Fast disintegrating drug delivery systems developed in the late s as an alternative to tablets, capsules, US food and drug administration, Center for Drug Evaluation and Research (CDER) defines, in the Orange book.

“an ODT as “a. Excipients in direct-compression ODT formulations A direct-compression ODT formulation usually contains diluent, disintegrant, lubricant, flow aid, flavor, sweetener, and often color.

A review of currently marketed ODT product labels shows that mannitol is a commonly used diluent or bulk excipient. The aim of study was to evaluate the effect of increasing epinephrine load on the characteristics of fast-disintegrating sublingual tablets for the potential emergency treatment of anaphylaxis.7 Sammour OA et al., have developed mouth dissolving.

Starch Starch is a polysaccharide carbohydrate consisting of a large number of glucose units joined together by glycosidic bonds. As a diluent, starch is used for the preparation of standardized triturates of colorants, potent drugs, and herbal extracts, facilitating subsequent mixing or blending processes in manufacturing operations.The invention relates to a pharmaceutical tablet for oral administration comprising ulipristal acetate together with the following excipients: at least one diluent in an amount of 50 to wt %, at least one binding agent in an amount of 0 to 10 wt %, at least one disintegrating agent in an amount of to 10 wt %, and at least one lubricant in an amount of 0 to 10 wt %.Cited by: SPH SPH FM IHBKNiazi-FM Char Count= Informa Healthcare USA, Inc.

52 Vanderbilt Avenue New York, NY C by Informa Healthcare USA, Inc. Informa Healthcare is an Informa business.